Improving Search Efficiency and Diversity of Solutions in Multiobjective Binary Optimization by Using Metaheuristics plus Integer Linear Programming.

Metaheuristics for solving multiobjective problems can provide an approximation of the Pareto front in a short time, but can also have difficulties finding feasible solutions in constrained problems. Integer linear programming solvers, on the other hand, are good at finding feasible solutions, but they can require some time to find and guarantee the efficient solutions of the problem. In this work we combine these two ideas to propose a hybrid algorithm mixing an exploration heuristic for multiobjective optimization with integer linear programming to solve multiobjective problems with binary variables and linear constraints. The algorithm has been designed to provide an approximation of the Pareto front that is well-spread throughout the objective space. In order to check the performance, we compare it with three popular metaheuristics using two benchmarks of multiobjective binary constrained problems. The results show that the proposed approach provides better performance than the baseline algorithms in terms of number of the solutions, hypervolume, generational distance, inverted generational distance, and the additive epsilon indicator.This research is partially funded by the Spanish Ministry of Economy and Competitiveness and FEDER under contract TIN2017-88213-R (6city); Universidad de Málaga, Consejería de Economía y Conocimiento de la Junta de Andaluía and FEDER under grant number UMA18-FEDERJA-003 (PRECOG); Spanish Ministry of Science, Innovation and Universities and FEDER under contracts RTC-2017-6714-5 (Eco-IoT) and RED2018-102472-T (SEBASENet 2.0); and TAILOR ICT-48 Network (No 952215) funded by EU Horizon 2020 research and innovation programme. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

La Geolocalización y el Reconocimiento Facial como apoyo en la Educación a Distancia de la Universidad Autónoma de Chihuahua.

La calidad en la educación virtual o a distancia (modalidades no convencionales) de la Universidad Autónoma de Chihuahua (UACH) requiere de la utilización de recursos tecnológicos para ser incrementada; el presente documento estudia las características, ventajas y desventajas de esta modalidad de estudios, haciendo un énfasis en la utilización de las tecnologías de la información para el desarrollo de ésta. Se realiza un análisis de dos Plataformas de Administración de Aprendizaje (LMS por sus siglas en inglés) para la gestión de cursos en línea: Blackboard y Moodle, destacando sus principales rasgos técnicos; para, a partir de ahí, hacer un estudio de la situación de la educación a distancia de la propia UACH, presentando datos estadísticos del comportamiento de la matrícula en los últimos años y concluir con la presentación de las características y modo de operar de la aplicación móvil desarrollada para implementar una validación por medio de geolocalización y de reconocimiento facial a la hora de realizar ciertas actividades en la plataforma Moodle, así como del tablero incorporado a la propia plataforma para apoyar la labor del docente y que éste conozca los resultados de las respectivas validaciones. DOI: https://doi.org/10.54167/tecnociencia.v14i1.62

Effective anytime algorithm for multiobjective combinatorial optimization problems

In multiobjective optimization, the result of an optimization algorithm is a set of efficient solutions from which the decision maker selects one. It is common that not all the efficient solutions can be computed in a short time and the search algorithm has to be stopped prematurely to analyze the solutions found so far. A set of efficient solutions that are well-spread in the objective space is preferred to provide the decision maker with a great variety of solutions. However, just a few exact algorithms in the literature exist with the ability to provide such a well-spread set of solutions at any moment: we call them anytime algorithms. We propose a new exact anytime algorithm for multiobjective combinatorial optimization combining three novel ideas to enhance the anytime behavior. We compare the proposed algorithm with those in the state-of-the-art for anytime multiobjective combinatorial optimization using a set of 480 instances from different well-known benchmarks and four different performance measures: the overall non-dominated vector generation ratio, the hypervolume, the general spread and the additive epsilon indicator. A comprehensive experimental study reveals that our proposal outperforms the previous algorithms in most of the instances.This research has been partially funded by the Spanish Ministry of Economy and Competitiveness (MINECO) and the European Regional Development Fund (FEDER) under contract TIN2017-88213-R (6city project), the European Research Council under contract H2020-ICT-2019-3 (TAILOR project), the University of Málaga, Consejería de Economía y Conocimiento de la Junta de Andalucía and FEDER under contract UMA18-FEDERJA-003 (PRECOG project), the Ministry of Science, Innovation and Universities and FEDER under contract RTC-2017-6714-5, and the University of Málaga under contract PPIT.UMA.B1.2017/07 (EXHAURO Project)

PARTICULARIDADES BIOLÓGICAS Y CONTROL CON EXTRACTOS VEGETALES DE Spodoptera frugiperda (J.E.SMITH) EN EL CULTIVO DEL MAÍZ / BIOLOGICAL PARTICULARITIES AND CONTROL WITH VEGETABLE EXTRACTS of Spodoptera frugiperda (J.E.SMITH) IN THE CULTURE OF CORN

El experimento se desarrolló en el Laboratorio de Entomología de la Facultad de Ciencias Agropecuarias de la Universidad Máximo Gómez Báez de Ciego de Ávila durante los años 2017 y 2019. El objetivo de nuestro trabajo es determinar las particularidades biológicas de Spodoptera frugiperda (J.E.Smith) y los extractos vegetales más efectivos para su control. Se determinaron las particularidades biológicas de Spodoptera frugiperda (J.E.Smith) según las metodologías de Gómez Souza, et al.(1990), Fumero, et al.(2004), Armas y Ayala, (1990) e Iparraguirre, (1998). El ciclo de vida de S. frugiperda se desarrolló en 28.5 días como promedio con una temperatura entre los 25 y 30 grados centígrados. Se probaron los extractos de Moringa masa fresca, Moringa masa seca ,Tithonia masa seca y de Tithonia masa fresca de 1:3 de concentración etanoica siendo a los 3 días la Moringa masa fresca en ambos casos la más efectiva logrando una mortalidad del 66,66 % seguido de la Moringa masa seca, Tithonia masa fresca que lograran un 55,55 % mostrando diferencia significativa. Posterior a los 3 días los extractos Tithonia masa fresca, Moringa masa fresca y Tithonia masa seca mostraron un excelente efecto residual en el control de Spodoptera frugiperda J.E.Smith pues lograron una mortalidad de 100, 88,88 y 66,66 % respectivamente

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. Keywords: Mediterranean diet; PREDIMED-plus study; cardiovascular health; liquid chromatography; mass spectrometry; plasma carotenoids

IV Foro Internacional de Ganadería Sustentable: conectividad ecosistémica y articulación territorial hacia la Agenda 2030

En este espacio plural de análisis y reflexiones, buscamos articular conceptos y posibilidades para los territorios de montaña del centro de México, dando importancia a medios de vida vinculados a la ganadería y su interacción ecosistémica, fundamentado en innovaciones, casos de éxito e iniciativas emblemáticas nacionales e internacionales. La socialización de experiencias es uno de los pilares para transitar hacia la sostenibilidad de los sistemas productivos ganaderos: compartir logros e iniciativas, crear sinergias e identificar vulnerabilidades desde distintos enfoques.GIZ, Agencia de Cooperación Aleman

Experiencias en el aula: cuarto encuentro de prácticas pedagógicas innovadoras.

Cuarto encuentro de prácticas pedagógicas innovadoras, evento que se llevo a cabo los días 7 y 8 de Octubre de 2019

Experiencias en el aula: cuarto encuentro de prácticas pedagógicas innovadoras.

Cuarto encuentro de prácticas pedagógicas innovadoras, evento que se llevo a cabo los días 7 y 8 de Octubre de 2019

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio